Coeliac Disease Description
Coeliac Disease
Excerpts from previous naturopathy assignment HLT60512
| Coeliac
Is a disease whereby the digestive system can’t metabolise gluten, adverse health effects occur from gluten consumption.
Signs and symptoms Atrophy and flattening of villi in the duodenum and jejunum of the SI Malabsorption nutrients T-cell antibody and complement activators Primary and Secondary effects of injury to villi and mucosal damage to the small intestine, Decreased surface area absorption and decreased intestinal hormones which results in inflammatory enteritis, decreased pancreatic function, decreased carbohydrate protein absorption, and fat absorption. Diarrhoea occurs due to malabsorption of food, decreased electrolytes and proteins are a result, which causes a vicious cycle of carb, protein, and fat malabsorption, ending in malnutrition (Craft, et al., 2011, p. 826) Research A study by Goebel 2017 reports: ‘A strong association exists between celiac disease and two human leukocyte antigen (HLA) haplotypes (DQ2 and DQ8). Damage to the intestinal mucosa occurs with the presentation of gluten-derived |
Testing
Hechtman 2012, gives the following examples: Organic acid profile IgG, IgE Food antibodies profile Coeliac profile and Gene screen Amino acid profile Nutrient and Toxic Elements (Hair, Blood) Adrenal Stress profile GI Function profile Secretory IgA Vitamin D Red cell or serum zinc and copper Urinary iodine (Hechtman, Clinical Naturopathic Medicine, 2012)
Naturopathic observational signs Diarrhea Bloating |
| peptide gliadin, consisting of 33 amino acids, by the HLA molecules to helper T cells. Helper T cells mediate the inflammatory response. Endogenous tissue transglutaminase deamidates gliadin into a negatively charged protein, increasing its immunogenicity. Absence of intestinal villi and lengthening of intestinal crypts characterize the mucosal lesions in untreated celiac disease. More lymphocytes infiltrate the epithelium (intraepithelial lymphocytes). Destruction of the absorptive surface of the intestine leads to a maldigestive and malabsorption syndrome. Celiac disease has a strong hereditary component. The prevalence of the condition in firstdegree relatives is approximately 10%’ (Goebel, 2017 ).
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Gas
Fatigue Weight Loss Iron-Deficiency Anemia Constipation Depression (Healthline, 2018) |
Heather Indiana Rose
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